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Laranja Amarga, a sua nova melhor amiga! (bônus +32 artigos científicos)



APENAS TENTE. A laranja amarga, fruto da Citrus aurantium, que é uma árvore pra lá de generosa (e poderosa) é um ansiolítico de grande qualidade e seguro para difusão aérea.


Quer mais alguns excelentes motivos para incluir esse OE na sua lista pessoal? Então lá vai:


O óleo essencial da casca do fruto da laranja amarga é rico em (+)-limoneno, mirceno e linalol. Estas moléculas são bastante conhecidas pela ciência. Veja essa pequena lista com alguns dos efeitos comprovados dos OEs dessa planta:


· possui atividade antitumoral,

· é ansiolítico*,

· melhora o sono,

· melhora o humor,

· trata cólicas e câimbras,

· é antimicrobiano,

· é gastroprotetivo,

· trata desordens digestivas,

· é um ótimo anti-inflamatório,

· é anticonvulsivante,

· ótimo antidepressivo,

· trata bronquite crônica e outras afecções das vias aéreas (sendo ativo inclusive contra pneumonia de origem bacteriana),

· é estimulante sexual,

· melhora a memória,

· trata obesidade,

· trata problemas cardíacos,

· trata epilepsia,

· é antioxidante, e

· produz um efeito imunoestimulante significativo, com uma influência sobre a quantidade de glóbulos brancos e produção de anticorpos pelo baço e medula espinhal.


De onde tiramos isso? Nos comentários tem uma listinha com 32 artigos científicos para você conferir e avaliar essas informações. Essa é uma das plantas mais estudadas do mundo!


A laranjeira é maravilhosa! Ela produz diferentes variedades de componentes voláteis: das flores, podemos colher o OE néroli; da casca dos frutos, extraímos o OE laranja amarga; das folhas, obtemos o OE petitgrain. Todos são excelentes ansiolíticos.


Uma difusão aérea desse óleo essencial por 20 minutos pode mudar o clima do seu dia!


*Para você ter ideia do poder desse OE, dentre os artigos da lista que vamos deixar nos comentários, dois papers brasileiros (da UFPB) avaliaram: 1 - o efeito ansiolítico do OE de laranja amarga em usuários de crack; 2 – o efeito ansiolítico do OE de laranja amarga em pacientes com leucemia mieloide crônica...



REFERÊNCIAS BIBLIOGRÁFICAS:


A High-throughput Quantitative Expression Analysis of Cancer-related Genes in Human HepG2 Cells in Response to Limonene, a Potential Anticancer Agent. Current Cancer Drug Targets (2018) 18: 807. https://doi.org/10.2174/1568009617666171114144236


Acridone alkaloids from the stem bark of Citrus aurantium display selective cytotoxicity against breast, liver, lung and prostate human carcinoma cells. Journal of Ethnopharmacology, Volume 227, 2018, Pages 131-138. https://doi.org/10.1016/j.jep.2018.08.039


An Overview on Citrus aurantium L.: Its Functions as Food Ingredient and Therapeutic Agent. Oxidative Medicine and Cellular Longevity, Volume 2018, Article ID 7864269. https://doi.org/10.1155/2018/7864269


Analgesic and anti-inflammatory activities of Citrus aurantium L. blossoms essential oil (neroli): involvement of the nitric oxide/cyclic-guanosine monophosphate pathway. J Nat Med 69, 324–331 (2015). https://doi.org/10.1007/s11418-015-0896-6


Anti-inflammatory Effect of Essential Oil from Citrus aurantium L. var. amara Engl. Journal of Agricultural and Food Chemistry 2017 65 (39), 8586-8594. https://doi.org/10.1021/acs.jafc.7b02586


Anti‐leukemic and anti‐angiogenic effects of D‐Limonene on K562‐implanted C57BL/6 mice and the chick chorioallantoic membrane model. Animal Model Exp Med . 2018; 1: 328– 333. https://doi.org/10.1002/ame2.12039


Anxiolytic Effect of Citrus aurantium L. in Crack Users. Evidence-Based Complementary and Alternative Medicine, Volume 2017, Article ID 7217619. https://doi.org/10.1155/2017/7217619


Anxiolytic Effect of Citrus aurantium L. on Patients with Chronic Myeloid Leukemia. Phytother. Res., 30: 613– 617. https://doi.org/10.1002/ptr.5566


Biochemical significance of limonene and its metabolites: future prospects for designing and developing highly potent anticancer drugs. Biosci Rep 21 December 2018; 38 (6): BSR20181253. https://doi.org/10.1042/BSR20181253


Bitter Orange (Citrus aurantium Linné) Improves Obesity by Regulating Adipogenesis and Thermogenesis through AMPK Activation. Nutrients 2019, 11, 1988. https://doi.org/10.3390/nu11091988


Chemical composition, antioxidant activity and antimicrobial activity of essential oil from Citrus aurantium L zest against some pathogenic microorganisms, Zeitschrift für Naturforschung C, 74(5-6), 105-111. https://doi.org/10.1515/znc-2018-0062


Citrus aurantium Aroma for Anxiety in Patients with Acute Coronary Syndrome: A Double-Blind Placebo-Controlled Trial. The Journal of Alternative and Complementary Medicine 2019 25:8, 833-839. https://doi.org/10.1089/acm.2019.0061


Citrus aurantium Blossom and Preoperative Anxiety. Brazilian Journal of Anesthesiology, Volume 61, Issue 6, 2011, Pages 702-712. https://doi.org/10.1016/S0034-7094(11)70079-4


Citrus aurantium L. dry extracts promote C/ebpβ expression and improve adipocyte differentiation in 3T3-L1 cells. PLOS ONE 13(3): e0193704. https://doi.org/10.1371/journal.pone.0193704


Citrus aurantium L. essential oil exhibits anxiolytic-like activity mediated by 5-HT1A-receptors and reduces cholesterol after repeated oral treatment. BMC Complement Altern Med 13, 42 (2013). https://doi.org/10.1186/1472-6882-13-42


Citrus aurantium L. exhibits apoptotic effects on U937 human leukemia cells partly through inhibition of Akt. International Journal of Oncology, 40, 2090-2096. https://doi.org/10.3892/ijo.2012.1350


Clinical Pharmacology of Citrus aurantium and Citrus sinensis for the Treatment of Anxiety. Evidence-Based Complementary and Alternative Medicine, Volume 2018, Article ID 3624094. https://doi.org/10.1155/2018/3624094


Comparative analysis of the antibacterial and drug-modulatory effect of d-limonene alone and complexed with β-cyclodextrin. European Journal of Pharmaceutical Sciences, Volume 128, 2019, Pages 158-161. https://doi.org/10.1016/j.ejps.2018.11.036


Comparing acupressure with aromatherapy using Citrus aurantium in terms of their effectiveness in sleep quality in patients undergoing percutaneous coronary interventions: A randomized clinical trial. Complementary Therapies in Clinical Practice. Volume 38, 2020, 101066. https://doi.org/10.1016/j.ctcp.2019.101066


Effects of Inhalation of Essential Oil of Citrus aurantium L. var. amara on Menopausal Symptoms, Stress, and Estrogen in Postmenopausal Women: A Randomized Controlled Trial. Evidence-Based Complementary and Alternative Medicine, Volume 2014, Article ID 796518. https://doi.org/10.1155/2014/796518


Essential oils as food eco-preservatives: Model system studies on the effect of temperature on limonene antibacterial activity. Food Chemistry, Volume 235, 2017, Pages 127-135. https://doi.org/10.1016/j.foodchem.2017.05.051


Flavonoids from Citrus aurantium ameliorate TNBS-induced ulcerative colitis through protecting colonic mucus layer integrity. European Journal of Pharmacology, Volume 857, 2019, 172456. https://doi.org/10.1016/j.ejphar.2019.172456


Gastroprotective effect of limonene in rats: Influence on oxidative stress, inflammation and gene expression. Phytomedicine, Volume 53, 2019, Pages 37-42. https://doi.org/10.1016/j.phymed.2018.09.027


Hypoglycemic and hypolipidemic effects of neohesperidin derived from Citrus aurantium L. in diabetic KK-Ay mice. Food Funct., 2015, 6, 878. https://doi.org/10.1039/C4FO00993B


Immune enhancement effects and extraction optimization of polysaccharides from Citrus aurantium L. var. amara Engl. Food Funct., 2017, 8, 796. https://doi.org/10.1039/C6FO01545J


Immunomodulatory Activity of Naturally Occurring Monoterpenes Carvone, Limonene, and Perillic Acid, Immunopharmacology and Immunotoxicology, 25:2, 285-294. https://doi.org/10.1081/IPH-120020476


Inhibition of DMBA-induced mammary cancer by the monoterpene d-limonene, Carcinogenesis, Volume 5, Issue 5, May 1984, Pages 661–664. https://doi.org/10.1093/carcin/5.5.661


Investigation of the effect of aromatherapy with Citrus aurantium blossom essential oil on premenstrual syndrome in university students: A clinical trial study. Complementary Therapies in Clinical Practice, Volume 32, 2018, Pages 1-5. https://doi.org/10.1016/j.ctcp.2018.04.006


Monoterpene limonene induces brown fat-like phenotype in 3T3-L1 white adipocytes. Life Sciences, Volume 153, 2016, Pages 198-206. https://doi.org/10.1016/j.lfs.2016.04.010


Polyphenols from Blossoms of Citrus aurantium L. var. amara Engl. Show Significant Anti-Complement and Anti-Inflammatory Effects. Journal of Agricultural and Food Chemistry 2017 65 (41), 9061-9068. https://doi.org/10.1021/acs.jafc.7b03759


Relationship between volatile components, antimicrobial and antioxidant properties of the essential oil, hydrosol and extracts of Citrus aurantium L. flowers. Journal of Infection and Public Health, Volume 13, Issue 1, 2020, Pages 58-67. https://doi.org/10.1016/j.jiph.2019.06.017


Various Antioxidant Effects Were Attributed to Different Components in the Dried Blossoms of Citrus aurantium L. var. amara Engl. Journal of Agricultural and Food Chemistry 2017 65 (30), 6087-6092. https://doi.org/10.1021/acs.jafc.7b02244



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Raissa e Ronan

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