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Laranja Amarga, a sua nova melhor amiga! (bônus +32 artigos científicos)



APENAS TENTE. A laranja amarga, fruto da Citrus aurantium, que é uma árvore pra lá de generosa (e poderosa) é um ansiolítico de grande qualidade e seguro para difusão aérea.


Quer mais alguns excelentes motivos para incluir esse OE na sua lista pessoal? Então lá vai:


O óleo essencial da casca do fruto da laranja amarga é rico em (+)-limoneno, mirceno e linalol. Estas moléculas são bastante conhecidas pela ciência. Veja essa pequena lista com alguns dos efeitos comprovados dos OEs dessa planta:


· possui atividade antitumoral,

· é ansiolítico*,

· melhora o sono,

· melhora o humor,

· trata cólicas e câimbras,

· é antimicrobiano,

· é gastroprotetivo,

· trata desordens digestivas,

· é um ótimo anti-inflamatório,

· é anticonvulsivante,

· ótimo antidepressivo,

· trata bronquite crônica e outras afecções das vias aéreas (sendo ativo inclusive contra pneumonia de origem bacteriana),

· é estimulante sexual,

· melhora a memória,

· trata obesidade,

· trata problemas cardíacos,

· trata epilepsia,

· é antioxidante, e

· produz um efeito imunoestimulante significativo, com uma influência sobre a quantidade de glóbulos brancos e produção de anticorpos pelo baço e medula espinhal.


De onde tiramos isso? Nos comentários tem uma listinha com 32 artigos científicos para você conferir e avaliar essas informações. Essa é uma das plantas mais estudadas do mundo!


A laranjeira é maravilhosa! Ela produz diferentes variedades de componentes voláteis: das flores, podemos colher o OE néroli; da casca dos frutos, extraímos o OE laranja amarga; das folhas, obtemos o OE petitgrain. Todos são excelentes ansiolíticos.


Uma difusão aérea desse óleo essencial por 20 minutos pode mudar o clima do seu dia!


*Para você ter ideia do poder desse OE, dentre os artigos da lista que vamos deixar nos comentários, dois papers brasileiros (da UFPB) avaliaram: 1 - o efeito ansiolítico do OE de laranja amarga em usuários de crack; 2 – o efeito ansiolítico do OE de laranja amarga em pacientes com leucemia mieloide crônica...



REFERÊNCIAS BIBLIOGRÁFICAS:


A High-throughput Quantitative Expression Analysis of Cancer-related Genes in Human HepG2 Cells in Response to Limonene, a Potential Anticancer Agent. Current Cancer Drug Targets (2018) 18: 807. https://doi.org/10.2174/1568009617666171114144236


Acridone alkaloids from the stem bark of Citrus aurantium display selective cytotoxicity against breast, liver, lung and prostate human carcinoma cells. Journal of Ethnopharmacology, Volume 227, 2018, Pages 131-138. https://doi.org/10.1016/j.jep.2018.08.039


An Overview on Citrus aurantium L.: Its Functions as Food Ingredient and Therapeutic Agent. Oxidative Medicine and Cellular Longevity, Volume 2018, Article ID 7864269. https://doi.org/10.1155/2018/7864269


Analgesic and anti-inflammatory activities of Citrus aurantium L. blossoms essential oil (neroli): involvement of the nitric oxide/cyclic-guanosine monophosphate pathway. J Nat Med 69, 324–331 (2015). https://doi.org/10.1007/s11418-015-0896-6


Anti-inflammatory Effect of Essential Oil from Citrus aurantium L. var. amara Engl. Journal of Agricultural and Food Chemistry 2017 65 (39), 8586-8594. https://doi.org/10.1021/acs.jafc.7b02586


Anti‐leukemic and anti‐angiogenic effects of D‐Limonene on K562‐implanted C57BL/6 mice and the chick chorioallantoic membrane model. Animal Model Exp Med . 2018; 1: 328– 333. https://doi.org/10.1002/ame2.12039


Anxiolytic Effect of Citrus aurantium L. in Crack Users. Evidence-Based Complementary and Alternative Medicine, Volume 2017, Article ID 7217619. https://doi.org/10.1155/2017/7217619


Anxiolytic Effect of Citrus aurantium L. on Patients with Chronic Myeloid Leukemia. Phytother. Res., 30: 613– 617. https://doi.org/10.1002/ptr.5566


Biochemical significance of limonene and its metabolites: future prospects for designing and developing highly potent anticancer drugs. Biosci Rep 21 December 2018; 38 (6): BSR20181253. https://doi.org/10.1042/BSR20181253


Bitter Orange (Citrus aurantium Linné) Improves Obesity by Regulating Adipogenesis and Thermogenesis through AMPK Activation. Nutrients 2019, 11, 1988. https://doi.org/10.3390/nu11091988


Chemical composition, antioxidant activity and antimicrobial activity of essential oil from Citrus aurantium L zest against some pathogenic microorganisms, Zeitschrift für Naturforschung C, 74(5-6), 105-111. https://doi.org/10.1515/znc-2018-0062


Citrus aurantium Aroma for Anxiety in Patients with Acute Coronary Syndrome: A Double-Blind Placebo-Controlled Trial. The Journal of Alternative and Complementary Medicine 2019 25:8, 833-839. https://doi.org/10.1089/acm.2019.0061


Citrus aurantium Blossom and Preoperative Anxiety. Brazilian Journal of Anesthesiology, Volume 61, Issue 6, 2011, Pages 702-712. https://doi.org/10.1016/S0034-7094(11)70079-4


Citrus aurantium L. dry extracts promote C/ebpβ expression and improve adipocyte differentiation in 3T3-L1 cells. PLOS ONE 13(3): e0193704. https://doi.org/10.1371/journal.pone.0193704


Citrus aurantium L. essential oil exhibits anxiolytic-like activity mediated by 5-HT1A-receptors and reduces cholesterol after repeated oral treatment. BMC Complement Altern Med 13, 42 (2013). https://doi.org/10.1186/1472-6882-13-42


Citrus aurantium L. exhibits apoptotic effects on U937 human leukemia cells partly through inhibition of Akt. International Journal of Oncology, 40, 2090-2096. https://doi.org/10.3892/ijo.2012.1350


Clinical Pharmacology of Citrus aurantium and Citrus sinensis for the Treatment of Anxiety. Evidence-Based Complementary and Alternative Medicine, Volume 2018, Article ID 3624094. https://doi.org/10.1155/2018/3624094


Comparative analysis of the antibacterial and drug-modulatory effect of d-limonene alone and complexed with β-cyclodextrin. European Journal of Pharmaceutical Sciences, Volume 128, 2019, Pages 158-161. https://doi.org/10.1016/j.ejps.2018.11.036


Comparing acupressure with aromatherapy using Citrus aurantium in terms of their effectiveness in sleep quality in patients undergoing percutaneous coronary interventions: A randomized clinical trial. Complementary Therapies in Clinical Practice. Volume 38, 2020, 101066. https://doi.org/10.1016/j.ctcp.2019.101066


Effects of Inhalation of Essential Oil of Citrus aurantium L. var. amara on Menopausal Symptoms, Stress, and Estrogen in Postmenopausal Women: A Randomized Controlled Trial. Evidence-Based Complementary and Alternative Medicine, Volume 2014, Article ID 796518. https://doi.org/10.1155/2014/796518


Essential oils as food eco-preservatives: Model system studies on the effect of temperature on limonene antibacterial activity. Food Chemistry, Volume 235, 2017, Pages 127-135. https://doi.org/10.1016/j.foodchem.2017.05.051


Flavonoids from Citrus aurantium ameliorate TNBS-induced ulcerative colitis through protecting colonic mucus layer integrity. European Journal of Pharmacology, Volume 857, 2019, 172456. https://doi.org/10.1016/j.ejphar.2019.172456


Gastroprotective effect of limonene in rats: Influence on oxidative stress, inflammation and gene expression. Phytomedicine, Volume 53, 2019, Pages 37-42. https://doi.org/10.1016/j.phymed.2018.09.027


Hypoglycemic and hypolipidemic effects of neohesperidin derived from Citrus aurantium L. in diabetic KK-Ay mice. Food Funct., 2015, 6, 878. https://doi.org/10.1039/C4FO00993B


Immune enhancement effects and extraction optimization of polysaccharides from Citrus aurantium L. var. amara Engl. Food Funct., 2017, 8, 796. https://doi.org/10.1039/C6FO01545J


Immunomodulatory Activity of Naturally Occurring Monoterpenes Carvone, Limonene, and Perillic Acid, Immunopharmacology and Immunotoxicology, 25:2, 285-294. https://doi.org/10.1081/IPH-120020476


Inhibition of DMBA-induced mammary cancer by the monoterpene d-limonene, Carcinogenesis, Volume 5, Issue 5, May 1984, Pages 661–664. https://doi.org/10.1093/carcin/5.5.661


Investigation of the effect of aromatherapy with Citrus aurantium blossom essential oil on premenstrual syndrome in university students: A clinical trial study. Complementary Therapies in Clinical Practice, Volume 32, 2018, Pages 1-5. https://doi.org/10.1016/j.ctcp.2018.04.006


Monoterpene limonene induces brown fat-like phenotype in 3T3-L1 white adipocytes. Life Sciences, Volume 153, 2016, Pages 198-206. https://doi.org/10.1016/j.lfs.2016.04.010


Polyphenols from Blossoms of Citrus aurantium L. var. amara Engl. Show Significant Anti-Complement and Anti-Inflammatory Effects. Journal of Agricultural and Food Chemistry 2017 65 (41), 9061-9068. https://doi.org/10.1021/acs.jafc.7b03759


Relationship between volatile components, antimicrobial and antioxidant properties of the essential oil, hydrosol and extracts of Citrus aurantium